Frailer tells the story of an actress playing a part that reflects her real life story. Whilst playing a woman dying of cancer, Muis her doctor tells her she has not much more time left. She will die soon. The film follows the transition of her and her film sisters, shifting from their characters to who they really are, actresses dealing with their friend upcoming death. We watch Leonoor become physically frailer but mentally stronger as she is slowly accepting her faith. Whilst ending the film, she leaves her film sisters, her real life husband and children but also the viewer, behind forever.